Cardiac complications in patients with community-acquired pneumonia: a systematic review and meta-analysis of observational studies.
PLoS Med. 2011 Jun;8(6):e1001048
Authors: Corrales-Medina VF, Suh KN, Rose G, Chirinos JA, D…

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What is the optimal therapy for patients with H5N1 influenza?

PLoS Med. 2009 Jun 23;6(6):e1000091

Authors: White NJ, Webster RG, Govorkova EA, Uyeki TM

BACKGROUND TO THE DEBATE: In a 2007 article in PLoS Medicine[10], Holger J. Schünemann and colleagues described a new process used by the World Health Organization for rapidly developing clinical management guidelines in emergency situations. These situations include outbreaks of emerging infectious diseases. The authors discussed how they developed such a "rapid advice" guideline for the pharmacological management of avian influenza A (H5N1) virus infection. The guideline recommends giving the antiviral drug oseltamivir at a dose of 75 mg twice daily for five days. In this Debate, Nicholas White argues that such dosing is inadequate, Robert Webster and Elena Govorkova say that combination antiviral therapy should be used, and Tim Uyeki reminds us that clinical care of patients with H5N1 entails much more than antiviral treatment. These issues may also apply to therapy of patients hospitalized with severe disease due to novel swine-origin influenza A (H1N1) virus infection.

PMID: 19554084 [PubMed - indexed for MEDLINE]

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No more free drug samples?

PLoS Med. 2009 May 5;6(5):e1000074

Authors: Chimonas S, Kassirer JP

Susan Chimonas and Jerome Kassirer argue that giving out “free” drug samples is not effective in improving drug access for the indigent, does not promote rational drug use, and raises the cost of care.

PMID: 19434227 [PubMed - indexed for MEDLINE]

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