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Dilated cardiomyopathy: a review.

J Clin Pathol. 2009 Mar;62(3):219-25

Authors: Luk A, Ahn E, Soor GS, Butany J

Dilated cardiomyopathy (DCM) is a common cardiac diagnosis that may result as a consequence of a variety of pathologies. The differential diagnosis remains quite broad since many pathologies can present as DCM, and as a result the approach to diagnosis may, at times, be quite difficult. This review article discusses genetic and acquired causes of DCM, pathophysiology of myocardial damage, pathology, and diagnostic criteria. An approach to management is also included, in the hope of informing physicians of a clinical entity that afflicts a substantial number of people worldwide.

PMID: 19017683 [PubMed - indexed for MEDLINE]

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Renal toxicity of therapeutic drugs.

J Clin Pathol. 2009 Jun;62(6):505-15

Authors: John R, Herzenberg AM

A number of therapeutic agents can adversely affect the kidney, resulting in tubulointerstitial, glomerular or vascular disease. Drug-induced tubulointerstitial nephritis and acute tubular necrosis are common, and are often cause by antibiotics or non-steroidal anti-inflammatory drugs. Drug-induced glomerular and vascular disease is relatively rare. This review describes the morphological patterns of drug-induced disease in the kidney. The histopathological changes are often similar to disease that is idiopathic or due to other causes, so that awareness and clinical correlation are most helpful to arrive at the aetiology.

PMID: 19474353 [PubMed - indexed for MEDLINE]

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