Nov 072012
 
Related Articles

Polypharmacy--we make it worse! A cross-sectional study from an acute admissions unit.

Intern Med J. 2012 Feb;42(2):208-11

Authors: Betteridge TM, Frampton CM, Jardine DL

Abstract

Although polypharmacy is a major problem in the elderly, very few data have been published from Australasia. We retrospectively audited 68% of elderly patients admitted acutely to our medical unit (n= 424, mean age 80.3 ± 8 years) during a 30-day period (September, 2008). We found that long-term medications increased during hospital stay from 6.6 ± 4 to 7.7 ± 4 (P < 0.001). Adverse drug reactions were responsible for 24 admissions (5.7%). Polypharmacy is made worse by acute admission to hospital.

PMID: 22356496 [PubMed - indexed for MEDLINE]

Link to Article at PubMed

Share


Jun 022012
 

Transfer from residential aged care to emergency departments: an analysis of patient outcomes.

Intern Med J. 2012 Jan;42(1):75-82

Authors: Arendts G, Dickson C, Howard K, Quine S

Abstract
BACKGROUND: In order to design optimal systems to meet the acute healthcare needs of the frail elderly living in residential care, good clinical information is essential. The aims of this study were to analyse the casemix and outcomes of patients transferred from residential aged care facilities to public hospital emergency departments in New South Wales.
METHODS: Individual patient data from six hospital emergency departments and inpatient wards were obtained from merged databases and analysed using descriptive and comparative statistics.
RESULTS: Outcomes in 4680 patient transfers over a 12-month period in 2006-2007 were analysed. Transfers occur mostly in high-acuity patients, with approximately three of every four transfers admitted; one in every 12 dying; and admitted patients undergoing an average of 2.4 interventions or procedures during each hospital stay. Several variables are associated with prolonged length of emergency department stay including triage urgency, type of hospital and transfers occurring in winter or out of hours.
CONCLUSIONS: Patients transferred from aged care facilities to emergency departments are predominantly high-acuity patients with a substantial likelihood of hospitalisation, intervention and death. Nevertheless, scope exists for some episodes of acute care, in both discharged and admitted patients, to be provided outside a hospital setting.

PMID: 20298507 [PubMed - indexed for MEDLINE]

Link to Article at PubMed

Share


Jun 022012
 

Simple approach to improving vancomycin dosing in intensive care: a standardised loading dose results in earlier therapeutic levels.

Intern Med J. 2012 Jan;42(1):23-9

Authors: Truong J, Levkovich BJ, Padiglione AA

Abstract
BACKGROUND: Patients in the Intensive Care Unit (ICU) often have sub-therapeutic vancomycin levels in the initial stages of therapy. Loading doses have been demonstrated to overcome this problem.
AIM: The aim of this study was to determine the impact of a standardised loading dose and increased clinician awareness of under-dosing on the achievement of early therapeutic vancomycin trough concentrations in the ICU.
METHODS: A pre- and post-intervention observational study was conducted in the ICU following the introduction of a 2-g vancomycin loading dose and demonstration of local under-dosing. All initial vancomycin trough levels were examined, except those from neurosurgical patients. Primary outcome measures were the proportion of patients achieving therapeutic vancomycin levels and mean trough concentrations. A year after introduction, a review was conducted to further assess the impact and sustainability of the intervention.
RESULTS: There were 31 courses of vancomycin in the pre-intervention period (no loading doses given) and 21 courses in the post-intervention period, of which 11 had a loading dose. In the pre-intervention group, 13% of courses achieved therapeutic concentrations. This increased to 33% in the post-intervention group (P= 0.08). A statistically significant increase in mean trough concentration, from 9.8 ± 6.6 mg/L to 14.9 ± 6.3 mg/L (P= 0.01), between the pre- and post-intervention groups was observed. During the follow-up period, results were similar to the post-intervention audit.
CONCLUSION: A standardised loading dose is a simple and sustainable intervention that may improve early achievement of therapeutic vancomycin levels in critically ill patients. The clinical significance of this requires further study.

PMID: 22276559 [PubMed - indexed for MEDLINE]

Link to Article at PubMed

Share


Mar 072012
 

Hospital doctors' attitudes towards older people.

Intern Med J. 2011 Apr;41(4):308-14

Authors: Leung S, Logiudice D, Schwarz J, Brand C

Abstract
BACKGROUND: Ageism among health professionals is increasingly recognized, but few studies investigated hospital doctors' attitudes towards older people. The aims of this study were to investigate hospital doctors' attitudes towards older people and to determine whether factors, which were identified in studies on other health professionals, influence hospital doctors' attitudes.
METHODS: Hospital doctors who worked in General Medicine or Aged Care units in two tertiary public hospitals in metropolitan Victoria, Australia, in 2008 were surveyed with Fraboni's Scale of Ageism (FSA), a validated instrument used to investigate attitudes towards older people. Demographic data from participants were collected.
RESULTS: Of the 235 questionnaires distributed, 122 were returned (overall response rate 51.9%). Response rate was highest among consultants (80.4%), followed by registrars (64.1%) and lowest among interns and residents (35.2%). The mean FSA score attained by the respondents was 61.5 (SD 11.0), representing a point between a neutral and a positive disposition. Doctors' characteristics that were associated with more positive attitudes towards older people included age of 30years or older (P < 0.001), female gender (P= 0.003), more senior in position (P < 0.001), postgraduate years of 10 or more (P < 0.001), previous working experience in Aged Care (P < 0.001), interest in Aged Care (P < 0.001) and more frequent social contacts with healthy older people (P < 0.001).
CONCLUSION: Hospital doctors of different demographic features and background characteristics display different attitudes towards older people. These findings can be used to inform future development of undergraduate and postgraduate medical curricula and form a basis for future studies on the effectiveness of these interventions in improving doctors' attitudes.

PMID: 20002850 [PubMed - indexed for MEDLINE]

Link to Article at PubMed

Share


Jul 012011
 

Use of empiric antimicrobial therapy in neutropenic fever. Australian Consensus Guidelines 2011 Steering Committee.

Intern Med J. 2011 Jan;41(1b):90-101

Authors: Tam CS, O'Reilly M, Andresen D, Lingaratnam S, Kelly A, Burbury K, Turnidge J, Slavin MA, Worth LJ, Dawson L, Thursky KA,

Administration of empiric antimicrobial therapy is standard practice in the management of neutropenic fever, but there remains considerable debate about the selection of an optimal regimen. In view of emerging evidence regarding efficacy and toxicity differences between empiric treatment regimens, and strong evidence of heterogeneity in clinical practice, the current guidelines were developed to provide Australian clinicians with comprehensive guidance for selecting an appropriate empiric strategy in the setting of neutropenic fever. Beta-lactam monotherapy is presented as the treatment of choice for all clinically stable patients while early treatment with combination antibiotic therapy is considered for patients at higher risk. Due consideration is given to the appropriate use of glycopeptides in this setting. Several clinical caveats, accounting for institution- and patient-specific risk factors, are provided to help guide the judicious use of the agents described. Detailed recommendations are also provided regarding time to first dose, timing of blood cultures, selection of a first-line antibiotic regimen, subsequent modification of antibiotic choice and cessation of therapy.

PMID: 21272173 [PubMed - indexed for MEDLINE]

Link to Article at PubMed

Share


Jul 012011
 

Use of antibacterial prophylaxis for patients with neutropenia. Australian Consensus Guidelines 2011 Steering Committee.

Intern Med J. 2011 Jan;41(1b):102-9

Authors: Slavin MA, Lingaratnam S, Mileshkin L, Booth DL, Cain MJ, Ritchie DS, Wei A, Thursky KA,

The use of oral prophylactic antibiotics in patients with neutropenia is controversial and not recommended by this group because of a lack of evidence showing a reduction in mortality and concerns that such practice promotes antimicrobial resistance. Recent evidence has demonstrated non-significant but consistent, improvement in all-cause mortality when fluoroquinolones (FQs) are used as primary prophylaxis. However, the consensus was that this evidence was not strong enough to recommend prophylaxis. The evidence base for FQ prophylaxis is presented alongside current consensus opinion to guide the appropriate and judicious use of these agents. Due consideration is given to patient risk, as it pertains to specific patient populations, as well as the net effect on selective pressure from antibiotics if FQ prophylaxis is routinely used in a target population. The potential costs and consequences of emerging FQ resistance, particularly among Escherichia coli, Clostridium difficile and Gram-positive organisms, are considered. As FQ prophylaxis has been advocated in some chemotherapy protocols, specific regard is given to whether FQ prophylaxis should be used to support these regimens. The group also provides recommendations for monitoring and surveillance of emerging resistance in those centres that have adopted FQ prophylaxis.

PMID: 21272174 [PubMed - indexed for MEDLINE]

Link to Article at PubMed

Share


  • Buy Cheapest overnight levitra Online Guaranteed Shipping. Best Drugstore.
  • Buy Cheapest buy black cialis without prescription Online Pharmacy Store. Cheap Online Pharmacy.
  • Buy Cheap generic cialis without prescription Online Top Online Pharmacy. WorldWide Shipping.
  • Buy Cheapest daily use cialis Now No Prescription Needed. Best Prices.
  • Buy Cheap best place to buy cialis jelly online here cheap Now No Prescription Needed. Cheap Pharmacy Online.
  • Buy Cheap cialis use with alcohol Now Best Internet. Special Prices For cialis use with alcohol!
  • Buy Cheap does viagra work reviews Now Online Medical Shop. Cheap Prescription Drugs.
  • Buy Cheap levitra drug information Now Best Online. Top Online Pharmacy Supplier.
  • Buy Cheapest does viagra means Online Best Internet. Cheap Pharmacy Online.
  • Buy Cheapest canadian generic cialis Now Low Prices. Cheap Prescription Drugs.
  • Buy Cheapest generic cialis cheapest lowest price Now Best Internet. Pharmacy At The Best Price!
  • Buy Cheapest dosage viagra Now Low Prices. Discount Pharmacy Online.
  • Buy Cheapest levitra effect Now Top Online Pharmacy. Cheap Online Pharmacy.
  • Buy Cheapest sildenafil order Now We Can Offer You Visit Our Online Pharmacy.
  • Buy Cheap cialis without a prescription paypal Now 100% Satisfaction Guaranteed. Best Online.
  • Buy Cheapest blue pills that get you high Now WorldWide Shipping. 24/Online Pharmacy.
  • Buy Cheap buy cialis online without prescription Now WorldWide Shipping. Guaranteed Shipping.
  • Buy Cheapest generic viagra online canada no prescription Now Top Online Pharmacy Supplier. Low Prices.
  • Buy Cheapest best price for generic viagra Now Pharmacy Store. Online Medical Shop.
  • Buy Cheapest viagra man song Now Cheap Online Pharmacy. Free Viagra Pills!
  • generic viagra professional Online Without Prescription Low Prices. Online Medical Shop.
  • Buy Cheapest buy cialis jelly without prescription Online Free Viagra Pills! Pharmacy Store.
  • Buy Cheap lowest price cialis online Now Guaranteed Shipping. Cheap Prescription Drugs.
  • Buy Cheap cialis without a prescription Online Pharmacy Store. Cheap Pharmacy Online.
  • Buy Cheap took viagra Now Pharmacy At The Best Price! Best Internet.
  • Buy Cheapest is viagra over the counter Now Guaranteed Shipping. 24/Online Pharmacy.
  • Buy Cheapest cheap cialis buy pharmacy online now Online Pharmacy Store. Free Viagra Pills!
  • Buy Cheapest australia viagra online without prescription Online Best Internet. Guaranteed Shipping.
  • Buy Cheap canadian meds cialis Now Low Prices. No Prescription Online Pharmacy.
  • Buy Cheap generic viagra price Now Guaranteed Shipping. Cheap Online Pharmacy.
  • Buy Cheapest buy viagra professional without prescription Now Best Prices. Discount Online Pharmacy.
  • Buy Cheapest viagra tablet price Online Low Prices. Special Prices For viagra tablet price!
  • Buy Cheap cost of cialis daily Now Free Viagra Pills! Internet Prices For cost of cialis daily!
  • Buying Cheapest buying without prescription levitra professional. Mexican Pharmacy, Best Prices. Best Prices.
  • Buy Cheapest is there generic cialis Online WorldWide Shipping. Best Internet.
  • Buy Cheapest on line prescriptions for cialis Now WorldWide Shipping. Cheap Pharmacy Online.
  • Buy Cheap viagra buy no prescription Now Order Cheap Meds Without Rx. Best Online.
  • Buy Cheap taking levitra Now Low Prices. Discount Online Pharmacy Shopping.
  • Buy Cheapest viagra next day Online Best Internet. Top Online Pharmacy.
  • Buy Cheap dose levitra Online Cheap Online Pharmacy. WorldWide Shipping.
  • Buy Cheapest generic viagra online pharmacy Online Discount Drugs At Best Online Drugstore.
  • Buy Cheap best place to buy cialis jelly online here cheap Online No Prescription Needed. Pharmacy Store.
  • Buy Cheapest levitra buy online no prescription Now Best Online. No Prescription Needed.
  • Buy Cheap ordering cialis online without prescription Now Pharmacy Store. Drugs, Health And Beauty.
  • Buy Cheap pills like viagra Online Low Prices. Cheap Prescription Drugs.
  • Buy Cheapest buy daily cialis from canada Now Pharmacy Store. No Prescription Needed.
  • Buy Cheap levitra effect Now Pharmacy At The Best Price! Best Online.
  • Buy Cheap order cialis online no prescription Now Free Viagra Pills! Internet Prices For order cialis online no prescription!
  • Buy Cheap generic viagra from india Online 24/Online Pharmacy. Best Drugstore.
  • Buy Cheapest order viagra online canada Now Best Online. Pharmacy At The Best Price!
  • Buy cialis pills levitra generic viagra Online Without Prescription. Best Online. Low Prices.
  • generic cialis 10mg Online Without Prescription WorldWide Shipping. Low Prices.
  • Buy Cheap search levitra Now Best Internet. Top Online Pharmacy Supplier.
  • Buy Cheap how long does a viagra tablet last Now Low Prices. No Prescription Needed For Drugs.
  • Buy Cheap cialis levitra Now Best Prices. Special Prices For cialis levitra!
  • Buy Cheap what's better viagra cialis levitra Online Free Viagra Pills! Cheap Pharmacy Online.
  • Buying Cheapest buy cialis jelly no prescription. Mexican Pharmacy, Best Prices. Best Prices.
  • Buy Cheapest compare generic viagra Online Cheap Pharmacy Online. Best Prices.
  • Buy Cheap cialis levitra Now Pharmacy Store. Special Prices For cialis levitra!
  • Buy Cheap medicine levitra 20mg Now Buy Medications Online. Free Viagra Pills!
  • Buy Cheap generic cialis no prescription Now Online Medical Shop. Discount Pharmacy Online.
  • Buy Cheapest how long does it take for cialis to work Now Top Online Pharmacy. WorldWide Shipping.
  • Buy Cheap viagra free Online Best Prices. No Prescription Needed.
  • Buy Cheap side effects of levitra Now Drugs, Health And Beauty. Guaranteed Shipping.
  • Buy Cheap viagra offers Online Discount Online Pharmacy. Pharmacy Store.
  • Buy Cheap order viagra online canada Online Low Prices. Cheap Prescription Drugs.
  • Buy Cheap cialis side effects alcohol Online Internet Prices For cialis side effects alcohol! Best Online.
  • Buy Cheap levitra professional safe Now Free Viagra Pills! Buy Medications Online.
  • Buy levitra 100mg pills Online Without Prescription. Pharmacy At The Best Price!
  • Buy Cheapest online buy cialis jelly without a prescription Online Best Internet. No Prescription Needed.
  • puerto rico cialis pictures Online Without Prescription Low Prices. WorldWide Shipping.
  • Buy Cheapest generic viagra 100mg Now Discount Online Pharmacy. Best Internet.
  • Buy Cheap levitra drug dosage Now Online Medical Shop. Discount Online Pharmacy.
  • side effects of viagra and alcohol Online Without Prescription Low Prices. Top Online Pharmacy.
  • Buy Cheapest levitra professional safe Now Pharmacy Store. Cheap Pharmacy Online.
  • Buy Cheap online pharmacy coupons Now FDA Approved Rx: Online Pharmacy. Low Prices.
  • Buy Cheapest cialis online without prescription Now Best Drugstore. Drugs, Health And Beauty.
  • Buy Cheap viagra online canada no prescription Now Best Online. No Prescription Needed For Drugs.
  • Buy Cheap cialis effect Online Best Drugstore. Discount Pharmacy Online.
  • Buy Cheapest super cialis pictures Now Best Internet. Drugs, Health And Beauty.
  • Buy Cheapest no prescription generic cialis Now Cheap Prescription Drugs. Pharmacy Store.
  • Buy Cheap generic cialis 10mg Online Pharmacy Store. No Prescription Needed.
  • Buy Cheap buy cheap generic viagra Online Best Internet. Special Prices For buy cheap generic viagra!
  • Buy Cheap does viagra means Online Free Viagra Pills! Online Medical Shop.
  • Buy Cheap viagra online pharmacy no prescription Now Best Prices. Internet Prices For viagra online pharmacy no prescription!
  • Buy Cheapest generic viagra us Online Top Online Pharmacy. Best Online.
  • Buy Cheapest discount generic viagra Online Guaranteed Shipping. Best Prices.
  • Buy Cheap best ed pill Online Best Drugstore. Top Online Pharmacy.
  • Buy Cheap comments viagra without a prescription Now Cheap Pharmacy Online. No Prescription Needed.
  • Buy Cheap viagra next day Now 100% Satisfaction Guaranteed. Best Internet.
  • Buy Cheapest free sample prescription for viagra Now Online Prices For free sample prescription for viagra! Best Internet.
  • Buy Cheap viagra blue Now The Largest Internet Pharmacy. Best Prices.
  • Buy Cheap purchase sildenafil citrate online Now Low Prices. No Prescription Needed For Drugs.
  • Buy Cheapest canada viagra online without prescription Online Guaranteed Shipping. Best Drugstore.
  • Buy Cheap uk alternative viagra Now Online Prices For uk alternative viagra! Guaranteed Shipping.
  • Buy Cheap blue prescription pills Online Best Online. Drugs, Health And Beauty.
  • Buy Cheap is it legal to buy viagra without a prescription Now 24/Internet)(safe Pharmacy. Low Prices.
  • Buy Cheap levitra review Now Order Cheap Meds Without Rx. Best Prices.
  • Buy Cheap generic viagra 50mg no prescription Now Pharmacy Store. Top Online Pharmacy Supplier.
  • Buy Cheapest viagra how works Now Best Online. 24/Internet)(safe Pharmacy.