Entries Tagged as 'Clin Microbiol Rev'
Epidemiology, etiology, pathogenesis, and diagnosis of recurrent bacterial meningitis.
Clin Microbiol Rev. 2008 Jul;21(3):519-37
Authors: Tebruegge M, Curtis N
Recurrent bacterial meningitis is a rare phenomenon and generally poses a considerable diagnostic challenge to the clinician. Ultimately, a structured approach and early diagnosis of any underlying pathology are crucial to prevent further episodes and improve the overall outcome for the affected individual. In this article, we are reviewing the existing literature on this topic over the last two decades, encompassing 363 cases of recurrent bacterial meningitis described in 144 publications. Of these cases, 214 (59%) were related to anatomical problems, 132 (36%) were related to immunodeficiencies, and 17 (5%) were related to parameningeal infections. The review includes a detailed discussion of the underlying pathologies and microbiological aspects as well as recommendations for appropriate diagnostic pathways for investigating this unusual entity.
PMID: 18625686 [PubMed - indexed for MEDLINE]
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Tags: Clin Microbiol Rev
Acinetobacter baumannii: emergence of a successful pathogen.
Clin Microbiol Rev. 2008 Jul;21(3):538-82
Authors: Peleg AY, Seifert H, Paterson DL
Acinetobacter baumannii has emerged as a highly troublesome pathogen for many institutions globally. As a consequence of its immense ability to acquire or upregulate antibiotic drug resistance determinants, it has justifiably been propelled to the forefront of scientific attention. Apart from its predilection for the seriously ill within intensive care units, A. baumannii has more recently caused a range of infectious syndromes in military personnel injured in the Iraq and Afghanistan conflicts. This review details the significant advances that have been made in our understanding of this remarkable organism over the last 10 years, including current taxonomy and species identification, issues with susceptibility testing, mechanisms of antibiotic resistance, global epidemiology, clinical impact of infection, host-pathogen interactions, and infection control and therapeutic considerations.
PMID: 18625687 [PubMed - indexed for MEDLINE]
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Tags: Clin Microbiol Rev
