Can Fam Physician

Entries Tagged as 'Can Fam Physician'

Hypertension in people with type 2 diabetes: Update on pharmacologic management.

September 16th, 2011 · Start a Discussion

Hypertension in people with type 2 diabetes: Update on pharmacologic management.
Can Fam Physician. 2011 Sep;57(9):997-1002
Authors: Campbell NR, Gilbert RE, Leiter LA, Larochelle P, Tobe S, Chockalingam A, Ward R, Morris D, T…

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Are family physicians using the CHADS2 score?: Is it useful for assessing risk of stroke in patients with atrial fibrillation?

August 16th, 2011 · Start a Discussion

Are family physicians using the CHADS2 score?: Is it useful for assessing risk of stroke in patients with atrial fibrillation?
Can Fam Physician. 2011 Aug;57(8):e305-9
Authors: Klein D, Levine M
Objective To assess whe…

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Falls in the elderly: Spectrum and prevention.

July 16th, 2011 · Start a Discussion

Falls in the elderly: Spectrum and prevention.
Can Fam Physician. 2011 Jul;57(7):771-776
Authors: Al-Aama T
Objective To provide family physicians with a practical, evidence-based approach to fall prevention in the eld…

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Venous access: a practical review for 2009.

August 27th, 2009 · Start a Discussion

Venous access: a practical review for 2009.

Can Fam Physician. 2009 May;55(5):494-6

Authors: Cheung E, Baerlocher MO, Asch M, Myers A

PMID: 19439704 [PubMed - indexed for MEDLINE]

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Treating prediabetes with metformin: systematic review and meta-analysis.

August 14th, 2009 · Start a Discussion

Treating prediabetes with metformin: systematic review and meta-analysis.

Can Fam Physician. 2009 Apr;55(4):363-9

Authors: Lilly M, Godwin M

OBJECTIVE: To determine if the use of metformin in people with prediabetes (impaired glucose tolerance or impaired fasting glucose) would prevent or delay the onset of frank type 2 diabetes mellitus. DATA SOURCES: MEDLINE was searched from January 1966 to the present, and articles meeting the selection criteria were hand searched. STUDY SELECTION: Randomized controlled trials that involved administration of metformin to delay or prevent type 2 diabetes in individuals with impaired glucose tolerance or impaired fasting glucose were included. Development of diabetes was a required outcome measure; follow-up time of at least 6 months was required. Three studies met these criteria. SYNTHESIS: The 3 studies varied in ethnicity of the population studied, in the rates of conversion to diabetes from prediabetes, and in the dose of metformin used. In general the studies were well done, although 2 of the 3 did not do true intention-to-treat analyses. A sensitivity analysis was completed by converting all data to intention-to-treat data and assuming a worst-case scenario for the people who were lost to follow-up. CONCLUSION: Metformin decreases the rate of conversion from prediabetes to diabetes. This was true at higher dosage (850 mg twice daily) and lower dosage (250 mg twice or 3 times daily); in people of varied ethnicity; and even when a sensitivity analysis was applied to the data. The number needed to treat was between 7 and 14 for treatment over a 3-year period.

PMID: 19366942 [PubMed - indexed for MEDLINE]

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Penicillins vs trimethoprim-based regimens for acute bacterial exacerbations of chronic bronchitis: meta-analysis of randomized controlled trials.

April 19th, 2009 · Start a Discussion

Penicillins vs trimethoprim-based regimens for acute bacterial exacerbations of chronic bronchitis: meta-analysis of randomized controlled trials.

Can Fam Physician. 2009 Jan;55(1):60-7

Authors: Korbila IP, Manta KG, Siempos II, Dimopoulos G, Falagas ME

OBJECTIVE: To compare the effectiveness and toxicity of semisynthetic penicillins (SSPs) (amoxicillin, ampicillin, pivampicillin) and trimethoprim-based regimens (trimethoprim, trimethoprim-sulfamethoxazole, trimethoprim-sulfadiazine) in treating acute bacterial exacerbations of chronic bronchitis (ABECB). DATA SOURCES: We searched MEDLINE, EMBASE, Current Contents, and the Cochrane Central Register of Controlled Trials to identify and extract data from relevant randomized controlled trials (RCTs). STUDY SELECTION: Only RCTs comparing penicillins with trimethoprim-based regimens for the treatment of patients with ABECB that reported data on effectiveness, toxicity, or mortality were considered eligible for this meta-analysis. SYNTHESIS: Out of 134 RCTs identified in the search, 5 RCTs involving 287 patients were included in the analysis. There were no differences between patients with ABECB treated with SSPs and those treated with trimethoprim, alone or in combination with a sulfonamide, in treatment success (intention-to-treat patients: n = 262, odds ratio [OR] 1.68, 95% confidence interval [CI] 0.91-3.09; clinically evaluable patients: n = 246, OR 1.59, 95% CI 0.79-3.20) or number of drug-related adverse events in general (n = 186 patients, OR 0.37, 95% CI 0.11-1.24), frequency of diarrhea or skin rashes, or number of withdrawals due to adverse events (n = 179 patients, OR 0.27, 95% CI 0.07-1.03). CONCLUSION: Based on limited evidence leading to wide CIs of the estimated treatment effects, SSPs and trimethoprim-based regimens seem to be equivalent in terms of effectiveness and toxicity for ABECB.

PMID: 19155372 [PubMed - indexed for MEDLINE]

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