Mar 122012
 

Combined copeptin and troponin to rule out myocardial infarction in patients with chest pain and a history of coronary artery disease.

Am J Emerg Med. 2012 Mar;30(3):440-8

Authors: Ray P, Charpentier S, Chenevier-Gobeaux C, Reichlin T, Twerenbold R, Claessens YE, Jourdain P, Riou B, Mueller C

Abstract
PURPOSE: The main objective of this multicentric study was to evaluate the additional value of copeptin to conventional cardiac troponin (cTn) for a rapid ruling out of acute myocardial infarction (AMI) in patients with acute chest pain and a previous history of coronary artery disease (CAD).
PATIENTS AND METHOD: Patients with a previous history of CAD presenting in the emergency department with acute chest pain lasting for 6 hours or less suggestive of non-ST-segment elevation AMI and negative cTn were selected. Levels of copeptin were blindly measured at presentation. The diagnosis was adjudicated by 2 independent experts using all available data including cTn.
RESULTS: A total of 451 patients were included (mean age, 67 ± 14; 330 [73%] men). The adjudicated final diagnosis was AMI in 36 (8%) patients, unstable angina in 131 (29%), and other diagnosis in 284 (63%). A negative cTn combined with a copeptin value lower than 10.7 pmol/L at presentation was able to rule out AMI, with a negative predictive value of 98% (95% confidence interval, 95%-99%).
CONCLUSION: In triage patients with acute chest pain lasting for less than 6 hours and a previous history of CAD, the combination of copeptin and cTn allows for the ruling out AMI, with a negative predictive value greater than 95%.

PMID: 22402136 [PubMed - in process]

Link to Article at PubMed

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Mar 122012
 

At Risk of Undertriage? Testing the Performance and Accuracy of the Emergency Severity Index in Older Emergency Department Patients.

Ann Emerg Med. 2012 Mar 6;

Authors: Grossmann FF, Zumbrunn T, Frauchiger A, Delport K, Bingisser R, Nickel CH

Abstract
STUDY OBJECTIVE: We test predictive validity, interrater reliability, and diagnostic accuracy of the Emergency Severity Index in older emergency department (ED) patients and identify reasons for inadequate triage. METHODS: We analyzed data of patients aged 65 years or older who were included in a prospective, single-center cohort study. Predictive validity was assessed by investigating associations of resources, disposition, length of stay, and mortality with Emergency Severity Index levels. Diagnostic accuracy was tested by calculating sensitivity and specificity of Emergency Severity Index level 1 for the prediction of a lifesaving intervention. For the assessment of interrater reliability, 2 experts independently reviewed the triage nurses' notes. Agreement was estimated as raw agreement and as Cohen's weighted ?. RESULTS: In total, 519 older patients were included. Emergency Severity Index level was associated with resource consumption (Spearman's ?=-0.449; 95% confidence interval [CI] -0.519 to -0.379), disposition (Kendall's ?=-0.452; 95% CI -0.516 to -0.387), ED length of stay (Kruskal-Wallis ?(2)=92.5; df=4; P<.001), and mortality (log-rank ?(2)=37.04; df=3; P<.001). The sensitivity of the Emergency Severity Index to predict lifesaving interventions was 0.462 (95% CI 0.232 to 0.709), and the specificity was 0.998 (95% CI 0.989 to 1.000). Interrater reliability between experts was high (raw agreement 0.917, 95% CI 0.894 to 0.944; Cohen's weighted ?(w)=0.934, 95% CI 0.913 to 0.954). Undertriage occurred in 117 cases. Main reasons were neglect of high-risk situations and failure to appropriately interpret vital signs. CONCLUSION: In our study, older patients were at risk for undertriage. However, our results suggest that the Emergency Severity Index is reliable and valid for triage of older patients.

PMID: 22401951 [PubMed - as supplied by publisher]

Link to Article at PubMed

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