Dec 152011
 

Procalcitonin-guided antibiotic therapy for chronic obstructive pulmonary disease exacerbations.

Expert Rev Anti Infect Ther. 2011 Jun;9(6):727-35

Authors: Tokman S, Schuetz P, Bent S

Abstract
The aim of this article is to review the current literature examining the use of procalcitonin-guided antibiotic therapy for management of chronic obstructive pulmonary disease (COPD) exacerbations. Procalcitonin is a serum marker that rises in response to bacterial infections, but remains low in nonbacterial infections and other proinflammatory conditions. To date, there are four randomized clinical trials which compare procalcitonin-guided antibiotic therapy to standard therapy in patients with COPD exacerbations. In all four trials the use of procalcitonin was associated with a reduction in antibiotic use (prescription and/or duration) without an increase in the rates of adverse patient outcomes including death, admission to the intensive care unit, re-exacerbation and readmission to the hospital. This data is clinically significant and suggests that the use of procalcitonin-guided antibiotic therapy has the potential to decrease unnecessary antibiotic use in nonbacterial COPD exacerbations, thereby curtailing the spread of antibiotic-resistant bacteria, reducing antibiotic-related adverse reactions, including Clostridium difficile infection, and potentially reducing healthcare costs.

PMID: 21692680 [PubMed - indexed for MEDLINE]

Link to Article at PubMed

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Dec 152011
 

Biomarkers in acute lung injury--marking forward progress.

Crit Care Clin. 2011 Jul;27(3):661-83

Authors: Barnett N, Ware LB

Abstract
This article reviews the state of the art regarding biomarkers for prediction, diagnosis, and prognosis in acute lung injury. Biomarkers and the goals of biomarker research are defined. Progress along 4 general routes is examined. First, the results of wide-ranging existing protein biomarkers are reported. Second, newer biomarkers awaiting or with strong potential for validation are described. Third, progress in the fields of genomics and proteomics is reported. Finally, given the complexity and number of potential biomarkers, the results of combining clinical predictors with protein and other biomarkers to produce better prognostic and diagnostic indices are examined.

PMID: 21742222 [PubMed - indexed for MEDLINE]

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Dec 152011
 

Patients leaving against medical advice (AMA) from the emergency department--disease prevalence and willingness to return.

J Emerg Med. 2011 Oct;41(4):412-7

Authors: Jerrard DA, Chasm RM

Abstract
BACKGROUND: How patients fare once they leave the emergency department (ED) against medical advice (AMA), and the extent of illness burden that accompanies them, remains unstudied.
OBJECTIVE: To determine the fate of patients leaving the ED AMA for a defined period of time post-discharge.
METHODS: This was a prospective follow-up study of a convenience sample of patients leaving the ED AMA during two 6-month periods in consecutive calendar years at an urban academic ED with 32,000 annual patient visits.
RESULTS: A total of 199 patients were identified, with 194 enrolled. Categories of discharge diagnoses included cardiovascular, undifferentiated abdominal pain, respiratory, and cellulitis. Of the 194 patients studied, 126 patients (64.9%, 95% confidence interval [CI] 57.6-71.5%) stated that their symptoms had improved or resolved. Of these 126 patients, 109 (86.5%, 95% CI 78.9-91.7%) had their original AMA discharge diagnoses referable to cardiovascular pathology. Ninety-five patients (75.4%, 95% CI 66.7-82.4%) with improved or abated symptoms did not plan to return. Of those with improved or abated symptoms, 31 patients (24.6%, 95% CI 17.6-33.2%) did return, and with further evaluation, 15 of them were found to have significant clinical findings. Of the 68 patients with continuing symptoms, 36 (52.9%, 95% CI 40.5-64.9%) returned for further evaluation. A total of 127 patients did not return. Twenty-five patients (19.7%, 95% CI 15.9-25.4%) expressed a reluctance to return to the same ED for fear of embarrassment. Seven patients (5.5%, 95% CI 4.8-8.7%) who did not seek alternative care but were still having symptoms did not return due to job or family commitments or because they would follow-up with a personal physician.
CONCLUSION: Patients who leave the ED AMA have significant pathology.

PMID: 20097503 [PubMed - indexed for MEDLINE]

Link to Article at PubMed

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Dec 152011
 

Introduction of the conducted electrical weapon into a hospital setting.

J Emerg Med. 2011 Sep;41(3):317-23

Authors: Ho JD, Clinton JE, Lappe MA, Heegaard WG, Williams MF, Miner JR

Abstract
BACKGROUND: The TASER(®) X26 Conducted Electrical Weapon (CEW) provides painful stimuli and neuromuscular incapacitation to potentially violent persons. Use by law enforcement in society is common. Presenting a CEW is known to de-escalate some situations. Health care personnel sometimes encounter violent persons within the confines of the hospital. CEW use by health care security personnel has not been described.
OBJECTIVE: The objective is to describe results from the introduction of the CEW into a hospital environment.
METHODS: Upon introducing the CEW into an urban hospital campus, standardized reports were made describing all CEW use by hospital security. Reports were retrospectively reviewed for the first 12 months of CEW use. Collected data included force options used, potential injuries avoided, witness comments, outcomes, and whether the CEW required full activation or if inactive presentation was sufficient to control the situation. Rates of security personnel injuries were also gathered. Descriptive analysis was applied.
RESULTS: Twenty-seven CEW deployments occurred: four were inactive presentation, 20 were presentation with LASER sight activation, and three were probe deployments with a 5-s delivery of electrical current. Two persons required evaluation for minor injuries not related to CEW use. Witnesses reported that in all incidents, injuries were likely avoided due to CEW presentation or use. CEW use aborted one suicide attempt. Personnel injury rates decreased during the study period.
CONCLUSION: CEW introduction into a health care setting demonstrated the ability to avert and control situations that could result in further injury to subjects, patients, and personnel. This correlates with a decrease in injury for hospital personnel. Further study is recommended for validation.

PMID: 20117901 [PubMed - indexed for MEDLINE]

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Dec 152011
 

Quantifying off-hour emergency physician coverage of in-hospital codes: a survey of community emergency departments.

J Emerg Med. 2011 Oct;41(4):381-5

Authors: Sherwin RL, Garcia AJ, Bilkovski R

Abstract
BACKGROUND: Community emergency physicians (EPs) are often required to respond to unstable patients outside of their department during off-hours.
OBJECTIVE: The primary objective of this study was to describe the critical care responsibility of community EPs outside of their departments.
METHODS: A one-page survey was mailed to emergency department (ED) directors of 10 states and Washington, DC.
RESULTS: Three hundred forty of 1169 surveys were returned. The median (interquartile range [IQR]) number of hospital and intensive care unit (ICU) beds was 145 (IQR 60-242) and 11 (IQR 6-20), respectively. Median ED annual volume and ICU admission percentage was reported to be 25K (IQR 14-40) and 5% (IQR 2-10), respectively. Seventy-six percent of reporting institutions require EPs to leave their department and respond to medical codes on the floors after hours. In 57% of institutions, the EP was the only physician required to respond. In addition, 48% of EPs must respond to unstable patients in the ICUs after hours. Hospitals in which EPs were required to respond to medical codes and unstable ICU patients were more likely to have fewer hospital beds (137 vs. 275; p<0.001), fewer ICU beds (12 vs. 27; p<0.001), and have a smaller ED annual volume (24 K vs. 39 K; p<0.001).
CONCLUSIONS: Many community EPs are responsible for covering critically ill patients outside of their ED. Further investigation is required to determine the impact on patient care.

PMID: 21215553 [PubMed - indexed for MEDLINE]

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Dec 152011
 

Impact of Carbapenem Resistance on Mortality in Pseudomonas aeruginosa Bloodstream Infections. A Prospective Multicenter Study.

Antimicrob Agents Chemother. 2011 Dec 12;

Authors: Peña C, Suarez C, Gozalo M, Murillas J, Almirante B, Pomar V, Aguilar M, Granados A, Calbo E, Rodríguez-Baño J, Rodríguez F, Tubau F, Martínez-Martínez L, Oliver A,

Abstract
The impact of antimicrobial resistance on clinical outcome is the subject of ongoing investigation, although uncertainty remains about its contribution to mortality. We investigated the impact of carbapenem resistance on mortality in Pseudomonas aeruginosa (PA) bacteremia in a prospective multicenter (ten teaching hospitals) observational study of patients with monomicrobial bacteremia followed up 30 days after bacteremia onset. The adjusted influence of carbapenem resistance on mortality was studied using Cox regression analysis. Of 632 episodes, 487 (77%) were caused by carbapenem-susceptible isolates (CSPA), and 145 (23%) by carbapenem-resistant (CRPA) isolates. The median incidence density of nosocomial CRPA bacteremia was 2.3 episodes per 100,000 patient-days (95%CI 1.9 to 2.8). The regression demonstrated a time-dependent effect of carbapenem resistance on mortality, as well as a significant interaction with the Charlson index: the deleterious effect of carbapenem resistance on mortality decreased with higher Charlson index scores. The impact of resistance on mortality was statistically significant only from the 5(th) day after the onset of the bacteremia, reaching its peak values at day 30 (adjusted hazard ratios [95% confidence intervals] Charlson 0 at day 30 = 9.9 [3.3 - 29.4]; Charlson 5 at day 30 = 2.6 [0.8 - 8]). This study clarifies the relationship between carbapenem resistance and mortality of patients with P. aeruginosa bacteremia. Although resistance was associated with a higher risk of mortality, the study suggested that this deleterious effect may be not as great during the first days of the bacteremia or in the presence of comorbidities.

PMID: 22155832 [PubMed - as supplied by publisher]

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