Nov 172011
 

Residents contributing to inpatient quality: Blending learning and improvement.

J Hosp Med. 2011 Nov 15;

Authors: Smith KL, Ashburn S, Rule E, Jervis R

Abstract
BACKGROUND: Quality improvement (QI) initiatives reduce medical errors and are an important aspect of resident physician training. Many institutions have limited funding and few QI experts, making it essential to develop effective programs that require only modest resources. We describe a resident-led, hospitalist-facilitated limited root cause analysis (RCA) QI program developed to meet training needs and institutional constraints. METHODS: We initiated a monthly quality improvement conference (QIC) at the Mount Sinai Hospital in New York City, New York. Before each conference, a third-year resident investigated a patient care issue and completed a limited RCA. At the QIC, the findings were presented to the Internal Medicine residents, followed by a chief resident and hospitalist-facilitated group discussion. All proposed interventions were recorded, and selected interventions were later implemented. The success of these interventions in achieving permanent system-wide change or resident behavior change was tracked. Residents' views on the conferences were solicited via an anonymous questionnaire. RESULTS: Twenty conferences were held over the first 22 months of the program. Twenty-five (54%) of the 46 suggested interventions were initiated. Eighteen (72%) attempted interventions resulted in system-wide change or resident behavior change. Fifty-three residents evaluated the quality of the conferences. The majority believed the conferences were high quality (98%) and led to patient care improvements (96%). CONCLUSIONS: Resident-led modified RCAs are an effective method of integrating QI efforts into resident training. As front line providers, residents are uniquely positioned to identify and implement system changes that benefit patients. Conferences were implemented without overburdening facilitators or participants. Journal of Hospital Medicine 2011;. © 2011 Society of Hospital Medicine.

PMID: 22086474 [PubMed - as supplied by publisher]

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Nov 172011
 

What every hospitalist should know about the post-bariatric surgery patient.

J Hosp Med. 2011 Nov 15;

Authors: Swanson CM, Roust LR, Miller K, Madura JA

Abstract
Obesity is a growing worldwide epidemic, increasingly addressed through surgical options for weight loss. Benefits of these operations, such as weight loss and improvement or reversal of obesity-related comorbidities, are well established; however, postoperative complications do occur. This article will evaluate common causes for hospital admissions in the post-bariatric surgery population as they relate to the hospitalist who is often responsible for their care. Here we provide an overview of the most common bariatric procedures currently performed, early postoperative complications, late medical complications (ie, abdominal complaints, weight fluctuations, nutritional deficiencies, and metabolic bone disease), and late surgical complications that often affect these patients and result in hospital admissions. Special attention will be paid to radiologic pearls that can assist in the initial evaluation and diagnosis of these patients. Journal of Hospital Medicine 2011;. © 2011 Society of Hospital Medicine.

PMID: 22086862 [PubMed - as supplied by publisher]

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Nov 172011
 

Treatment of Unexplained Syncope: A Multicenter, Randomized Trial of Cardiac Pacing Guided by Adenosine 5'-triphosphate Testing.

Circulation. 2011 Nov 15;

Authors: Flammang D, Church TR, De Roy L, Blanc JJ, Leroy J, Mairesse GH, Otmani A, Graux PJ, Frank R, Purnode P

Abstract
BACKGROUND: -The origin of 40% of syncope cases remains unknown even after a complete diagnostic work-up. Previous studies have suggested that adenosine 5'-triphosphate (ATP) testing has value in selecting successful therapy. This patient-blinded, multicenter, randomized superiority trial tested whether, in patients with syncope of unknown origin (SUO), selecting cardiac pacing in those with a positive ATP test results in fewer recurrences than those who do not receive pacing. METHODS AND RESULTS: -From 2000 to 2005, 80 consenting patients (mean age 75.9 ± 7.7 years, 81% women, and 56% without diagnosed structural heart disease) with SUO and atrioventricular or sinoatrial block lasting longer than 10 seconds (average 17.9 ± 6.8 seconds) under ATP administration (20 mg IV bolus) were recruited from 10 hospitals, implanted with programmable pacemakers, and randomized to either active pacing (dual-chamber pacing at 70 beats per minute [bpm]) or backup pacing (atrial pacing at 30 bpm). Patients were followed regularly for up to five years for any syncope recurrence, the primary outcome. Mean follow-up was 16 months. Syncope recurred in eight (21%) of 39 patients randomized to active pacing and in 27 (66%) of 41 randomized to backup pacing (control), yielding a hazard ratio of 0.25 (95% CI: 0.12, 0.56). After recurrence, the 27 recurrent control patients were reprogrammed to active pacing and only one reported subsequent syncope. CONCLUSIONS: -This study suggests that, in elderly patients with SUO and positive ATP tests, active dual-chamber pacing reduces syncope recurrence risk by 75% (95% CI 44% to 88%).Clinical Trial Registration Information-http://www.controlled-trials.com/ISRCTN00029383; Unique Identifier: ISRCTN00029383.

PMID: 22086879 [PubMed - as supplied by publisher]

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Nov 172011
 

Liraglutide: A Review of its Use in the Management of Type 2 Diabetes Mellitus.

Drugs. 2011 Dec 3;71(17):2347-2373

Authors: Perry CM

Abstract
Liraglutide (Victoza®) is a subcutaneously administered glucagon-like peptide-1 (GLP-1) receptor agonist produced by recombinant DNA technology and used as an adjunct to diet and exercise in the treatment of adults with type 2 diabetes mellitus. This article reviews the clinical efficacy and tolerability of liraglutide in adults with type 2 diabetes, and provides a summary of its pharmacological properties. Recently published pharmacoeconomic studies of liraglutide are also reviewed. Administered subcutaneously, liraglutide (usually 1.2 or 1.8?mg once daily) generally produced greater improvements in glycaemic control than active comparators or placebo when administered as monotherapy or in combination with one or two oral antidiabetic drugs (OADs) to adults with type 2 diabetes in numerous randomized, controlled phase III trials. These included six trials in the LEAD trial programme that was designed to evaluate the efficacy and safety of liraglutide across a continuum of antihyperglycaemic management for patients with type 2 diabetes. Liraglutide was generally well tolerated, with a low risk of hypoglycaemia evident, in the phase III trials. The most common adverse events were gastrointestinal and included nausea and diarrhoea; most events were mild to moderate in severity and decreased in incidence over time. In conclusion, liraglutide has an important place in the management of adults with type 2 diabetes across a continuum of care. As well as providing effective glycaemic control, liraglutide improves pancreatic ?-cell function and leads to bodyweight loss, thereby addressing some of the unmet needs of patients treated with traditional OADs.

PMID: 22085389 [PubMed - as supplied by publisher]

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Nov 172011
 

Anaphylaxis: Recognition and Management.

Am Fam Physician. 2011 Nov 15;84(10):1111-1118

Authors: Arnold JJ, Williams PM

Abstract
Anaphylaxis is a severe, life-threatening, systemic allergic reaction that is almost always unanticipated and may lead to death by airway obstruction or vascular collapse. Anaphylaxis occurs as the result of an allergen response, usually immunoglobulin E-mediated, which leads to mast cell and basophil activation and a combination of dermatologic, respiratory, cardiovascular, gastrointestinal, and neurologic symptoms. Dermatologic and respiratory symptoms are most common, occurring in 90 and 70 percent of episodes, respectively. The three most common triggers are food, insect stings, and medications. The diagnosis of anaphylaxis is typically made when symptoms occur within one hour of exposure to a specific antigen. Confirmatory testing using serum histamine and tryptase levels is difficult, because blood samples must be drawn with strict time considerations. Allergen skin testing and in vitro assay for serum immunoglobulin E of specific allergens do not reliably predict who will develop anaphylaxis. Administration of intramuscular epinephrine at the onset of anaphylaxis, before respiratory failure or cardiovascular compromise, is essential. Histamine H1 receptor antagonists and corticosteroids may be useful adjuncts. All patients at risk of recurrent anaphylaxis should be educated about the appropriate use of prescription epinephrine autoinjectors.

PMID: 22085665 [PubMed - as supplied by publisher]

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Nov 172011
 

Dronedarone in Atrial Fibrillation - Jekyll and Hyde?

N Engl J Med. 2011 Nov 14;

Authors: Nattel S

Abstract
Atrial fibrillation, the most common type of sustained cardiac arrhythmia, is associated with increased morbidity and mortality and is often therapeutically challenging.(1) Dronedarone is a recently introduced antiarrhythmic drug that was developed by modifying the structure of amiodarone in an effort to reduce toxicity and improve pharmacokinetic properties.(1) Dronedarone has properties of all of the major classes of antiarrhythmic drugs.(1) In the ATHENA trial (A Placebo-Controlled, Double-Blind, Parallel Arm Trial to Assess the Efficacy of Dronedarone 400 mg bid for the Prevention of Cardiovascular Hospitalization or Death from Any Cause in Patients with Atrial Fibrillation/Atrial Flutter; ClinicalTrials.gov number, NCT00174785),(2) dronedarone . . .

PMID: 22082122 [PubMed - as supplied by publisher]

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