Apr 032011
 

Hyponatremia and risk of seizures: a retrospective cross-sectional study.

Epilepsia. 2011 Feb;52(2):410-3

Authors: Halawa I, Andersson T, Tomson T

This retrospective cross-sectional study was carried out to study the association between different levels of hyponatremia and the occurrence of epileptic seizures in patients without a prior epilepsy diagnosis. We identified from the hospital database, 363 inpatients of a Swedish County hospital who between March 2003 and August 2006 were found to have serum sodium levels <125 mM. Medical records were reviewed and we identified 11 patients with seizures in conjunction with their hyponatremia. Seizures were the only neurologic manifestation of hyponatremia in patients with serum sodium levels >115 mM. Of 150 patients reviewed with serum sodium levels of 120-124 mM, one had a seizure. Using 120-124 mM as reference, odds ratios (95% confidence interval) for having seizures at serum sodium levels of 115-119 mM was 3.85 (0.40-37.53), 8.43 (0.859-82.85) at 110-114 mM, and 18.06 (1.96-166.86) at <110 mM.

PMID: 21314679 [PubMed - indexed for MEDLINE]

Link to Article at PubMed

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Apr 032011
 

A Comparative Effectiveness Trial Between a Post-Acute Care Hospitalist Model and a Community-Based Physician Model of Nursing Home Care.

J Am Med Dir Assoc. 2010 Dec 20;

Authors: Gloth FM, Gloth MJ

INTRODUCTION: To evaluate whether a designated Post-Acute Care Hospitalist (PACH) (an individual physician charged with care of most residents in the nursing home and with set hours to be in the facility each week) could improve some measureable outcomes in the long-term care setting compared with a traditional cadre of community physicians, a comparative trial was designed to measure multiple cost and care variables. METHODS: Data were collected in a historical prospective study design for 6 months before the institution of a PACH model in a nursing home in the Baltimore area. Similar data were collected in a similar setting in the same region during the same time frame. During the same 6 months in the following year (ending June 30, 2008) after initiating the PACH program, the same outcome measures, which included demographic information, admissions per census, number of medications per resident, laboratory services and fees per resident day, fallers and falls per resident day, unplanned discharges per resident day, and average pharmacy costs per patient, were collected. RESULTS: Demographic information was similar in all groups. PACH and non-PACH models per resident day were significantly different for laboratory tests (intrafacility pre-PACH $1.93, post-PACH $2.97; P < .005 and interfacility post-PACH $2.97, non-PACH $0.97), fallers (intrafacility pre-PACH 0.006, post-PACH 0.008; P = .01 and interfacility post-PACH 0.008, non-PACH 0.006; P < .005), and falls (intrafacility pre-PACH 0.007, post-PACH 0.01; P < .05 and interfacility post-PACH 0.01, non-PACH 0.008; P < .05). Medication errors after PACH was instituted were 1/6 of pre-PACH rate and 1/60 of the non-PACH facility. Post-PACH pharmacy costs were also better than the non-PACH facility pharmacy costs per resident day by $7.74, but differences for medication errors and pharmacy costs were not statistically significant. CONCLUSION: Institution of a PACH in a nursing home was associated with a significant increase in laboratory costs and no improvement in fall rates. There was a nonsignificant reduction in medication errors and pharmacy costs. These data support the hypothesis that a PACH model may lead to greater clinician involvement, which may be associated with an increase in clinical testing and a decrease in pharmacy costs and medication errors. If true, the latter would likely far offset any costs associated with additional laboratory testing. These findings warrant further investigation of larger magnitude.

PMID: 21450218 [PubMed - as supplied by publisher]

Link to Article at PubMed

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Apr 032011
 

Diagnosis and therapy of ascites in liver cirrhosis.

World J Gastroenterol. 2011 Mar 14;17(10):1237-48

Authors: Biecker E

Ascites is one of the major complications of liver cirrhosis and is associated with a poor prognosis. It is important to distinguish noncirrhotic from cirrhotic causes of ascites to guide therapy in patients with noncirrhotic ascites. Mild to moderate ascites is treated by salt restriction and diuretic therapy. The diuretic of choice is spironolactone. A combination treatment with furosemide might be necessary in patients who do not respond to spironolactone alone. Tense ascites is treated by paracentesis, followed by albumin infusion and diuretic therapy. Treatment options for refractory ascites include repeated paracentesis and transjugular intrahepatic portosystemic shunt placement in patients with a preserved liver function. Potential complications of ascites are spontaneous bacterial peritonitis (SBP) and hepatorenal syndrome (HRS). SBP is diagnosed by an ascitic neutrophil count > 250 cells/mm(3) and is treated with antibiotics. Patients who survive a first episode of SBP or with a low protein concentration in the ascitic fluid require an antibiotic prophylaxis. The prognosis of untreated HRS type 1 is grave. Treatment consists of a combination of terlipressin and albumin. Hemodialysis might serve in selected patients as a bridging therapy to liver transplantation. Liver transplantation should be considered in all patients with ascites and liver cirrhosis.

PMID: 21455322 [PubMed - in process]

Link to Article at PubMed

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Apr 032011
 

Impact of heart failure on in-hospital outcomes of acute coronary syndrome patients in China - Results from the Bridging the Gap on CHD Secondary Prevention in China (BRIG) project.

Int J Cardiol. 2011 Mar 29;

Authors: Wang N, Zhao D, Liu J, Liu J, Yu CM, Wang W, Sun J, Li Y, Du F,

BACKGROUND: Treatments of acute coronary syndrome (ACS) and heart failure (HF) have progressed greatly in the past decades. However, few data are currently available regarding the impact of HF on the in-hospital outcomes of ACS patients, under current treatment status, in China. METHODS: A total of 65 hospitals from all 31 provinces of mainland China and the Hong Kong special administrative region were recruited using a multistage non-randomized sampling approach. A questionnaire was completed according to the medical records of 3168 ACS patients, of which 706 (22.3%) had acute HF and 262 (8.3%) HF patients did not have an episode of acute HF during hospitalization. RESULTS: The rates of in-hospital mortality and composite end-point events (death, myocardial re-/infarction, serious arrhythmia and stroke) of acute HF patients were significantly higher than those of HF patients without an acute episode and patients without HF. After adjustment for other factors (including age, ACS types and in-hospital treatments, etc.), acute HF remained to be a potent independent predictor of in-hospital mortality and composite end-point events for ACS patients (OR=7.50, 95% CI=4.32-13.02 and OR=2.74, 95% CI=2.15-3.48, respectively). The utilization rates of guideline recommended treatments for ACS complicating HF, such as ?-blockers (67.6%) and PCI (17.4%), were low in the acute HF patients. CONCLUSIONS: Under current treatment status, acute HF during hospitalization still rendered higher rates of in-hospital mortality and composite end-point events in the studied ACS patients in China.

PMID: 21453979 [PubMed - as supplied by publisher]

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Apr 032011
 

The use of antiarrhythmic drugs for adult cardiac arrest: A systematic review.

Resuscitation. 2011 Mar 26;

Authors: Ong ME, Pellis T, Link MS

AIMS: In adult cardiac arrest, antiarrhythmic drugs are frequently utilized in acute management and legions of medical providers have memorized the dosage and timing of administration. However, data supporting their use is limited and is the focus of this comprehensive review. METHODS: Databases including PubMed, Cochrane Library (including Cochrane database for systematic reviews and Cochrane Central Register of Controlled Trials), Embase, and AHA EndNote Master Library were systematically searched. Further references were gathered from cross-references from articles and reviews as well as forward search using SCOPUS and Google scholar. The inclusion criteria for this review included human studies of adult cardiac arrest and anti-arrhythmic agents, peer-review. Excluded were review articles, case series and case reports. RESULTS: Of 185 articles found, only 25 studies met the inclusion criteria for further review. Of these, 9 were randomised controlled trials. Nearly all trials solely evaluated Ventricular Tachycardia (VT) and Ventricular Fibrillation (VF), and excluded Pulseless Electrical Activity (PEA) and asystole. In VT/VF patients, amiodarone improved survival to hospital admission, but not to hospital discharge when compared to lidocaine in two randomized controlled trials. CONCLUSION: Amiodarone may be considered for those who have refractory VT/VF, defined as VT/VF not terminated by defibrillation, or VT/VF recurrence in out of hospital cardiac arrest or in-hospital cardiac arrest. There is inadequate evidence to support or refute the use of lidocaine and other antiarrythmic agents in the same settings.

PMID: 21444143 [PubMed - as supplied by publisher]

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Apr 032011
 

In-hospital cardiac arrest: Impact of monitoring and witnessed event on patient survival and neurologic status at hospital discharge.

Resuscitation. 2011 Mar 29;

Authors: Brady WJ, Gurka KK, Mehring B, Peberdy MA, O'Connor RE,

CONTEXT: In-hospital cardiac arrest is a significant public health problem with a low probability of patient survival to hospital discharge. OBJECTIVE: We evaluated the survival rates for adults with in-hospital cardiac arrest based on whether the arrest was witnessed and/or monitored. Our hypothesis is that patients with either a witnessed or monitored arrest had improved survival to hospital discharge with intact neurologic function. DESIGN, SETTING, AND PATIENTS: We studied a cohort study of 74,213 patients who suffered in-hospital cardiac arrest from January 1, 2000 through February 1, 2008 at the 369 hospitals participating in the National Registry of Cardiopulmonary Resuscitation. INTERVENTIONS: The primary exposure of interest was whether the arrest was witnessed and/or monitored (i.e. electrocardiography, pulse oximetry, apnea, or bradycardia monitoring) at the time of arrest. Events were classified as being both monitored and witnessed, monitored only, witnessed only, or neither witnessed nor monitored. MAIN OUTCOME MEASURES: Survival to hospital discharge and cerebral performance category at time of discharge. RESULTS: A total of 73% of patients suffering in-hospital cardiac arrest were witnessed and monitored; 10% were monitored but not witnessed; 9% were witnessed but not monitored; and 8% were neither witnessed nor monitored. Compared with those who were unmonitored/unwitnessed, each of the three groups of patients who were monitored and/or witnessed were over twice as likely to survive to hospital discharge with a cerebral performance category of 1 or 2 (monitored/witnessed OR=2.40, 95% CI: 2.08, 2.76; monitored-only OR=2.12, 95% CI: 1.81, 2.47; witnessed-only OR=2.43, 95% CI: 2.10, 2.83). CONCLUSIONS: Patients who are witnessed and/or monitored at the time of cardiac arrest demonstrate a significantly higher rate of survival to hospital discharge compared to those patients who are neither monitored nor witnessed. Monitored and/or witnessed cardiac arrest patients were also more likely to be discharged with favorable neurologic outcome. Cardiac monitoring confers no additional outcome benefit over direct observation of patients suffering in-hospital cardiac arrest.

PMID: 21454008 [PubMed - as supplied by publisher]

Link to Article at PubMed

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