Trends among pathogens reported as causing bacteraemia in England, 2004 to 2008.

Link to article at PubMed

Trends among pathogens reported as causing bacteraemia in England, 2004 to 2008.

Clin Microbiol Infect. 2010 May 18;

Authors: Wilson J, Elgohari S, Livermore DM, Cookson B, Johnson A, Lamagni T, Chronias A, Sheridan E

Abstract The Health Protection Agency in England operates a voluntary surveillance system that collects data on bacteraemias reported by over 90% of laboratories in England. Trends in causative microorganisms reported between 2004 and 2008 were analysed using a generalised linear model with a log link function for Poisson distribution. In 2008, 101 276 episodes of bacteraemia were reported; a rate of 189 per 100 000 population. More than half occurred in the over-65s and males. The most common organisms reported were Escherichia coli (23%), coagulase-negative staphylococci (CNS) (16.9%) and Staphylococcus aureus (11.4%). Between 2004 and 2008 E. coli bacteraemia increased by 33% (p < 0.001); the species now accounts for more than 30% of bacteraemia in those over 75 years. There also were significant increases in bacteraemia caused by other Gram-negative pathogens and marked seasonal variation. Bacteraemia caused by S. aureus increased until 2005, with a decline after 2006 (p < 0.001) entirely due to methicillin-resistant strains. CNS bacteraemia have declined significantly since 2007. The renewed dominance of Gram-negative pathogens as major causes of bacteraemia in England is of particular concern as they are associated with a high morbidity and increasing resistance to antibiotics. Further investigation of underlying causes and prevention strategies is a public health priority. Recent declines in MRSA bacteraemia have not been reflected in other pathogens, including methicillin-susceptible S. aureus.

PMID: 20491834 [PubMed - as supplied by publisher]

Leave a Reply

Top