Jun 152009
 
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Evidence-based renal replacement therapy for acute kidney injury.

Minerva Anestesiol. 2009 Mar;75(3):135-9

Authors: Zarbock A, Singbartl K, Kellum JA

Acute kidney injury (AKI) with the subsequent need for renal replacement therapy (RRT) represents a persistent challenge, arising in 4-5% in critically-ill patients, and remains associated with a high mortality (60%) and morbidity. As AKI is an independent risk factor for poor prognosis, appropriate management of patients with AKI becomes of utmost importance. Complications of AKI can be treated with different forms of RRT, such as continuous veno-venous hemofiltration or intermittent hemodialysis. However, the timing of the initiation, the modality, and the dose of RRT are still controversial and the subject of ongoing clinical trials. This review presents and discusses currently available data regarding the use of RRT in critically-ill patients with AKI.

PMID: 18475252 [PubMed - indexed for MEDLINE]

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Jun 152009
 
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Palliation of malignant obstructive jaundice.

Dig Dis Sci. 2009 Jun;54(6):1184-98

Authors: Garcea G, Ong SL, Dennison AR, Berry DP, Maddern GJ

Peri-ampullary and hepatic malignancies will frequently present with obstructive jaundice. For unresectable tumors, effective and lasting decompression of the biliary tree is essential to improve quality of life and survival. An overview of present treatment modalities for palliation of obstructive jaundice is provided, including a systematic review of the English literature regarding the optimum choice of palliation.

PMID: 18770035 [PubMed - indexed for MEDLINE]

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Jun 152009
 
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The needs of members of the families of general hospital inpatients.

Sao Paulo Med J. 2008 Mar 6;126(2):128-31

Authors: Lucchese AC, Citero Vde A, De Marco MA, Andreoli SB, Nogueira-Martins LA

CONTEXT AND OBJECTIVE: The needs of members of the families of intensive care unit patients have been studied, but little is known about the needs of members of the families of general hospital inpatients, especially patients with chronic diseases. The aim of this study was to identify the needs of members of the families of general hospital inpatients and investigate associations between these needs and the patients' clinical and psychiatric profiles. DESIGN AND SETTING: Descriptive study, in a public teaching hospital. METHODS: A random sample of 47 patients and members of their families was studied. Family members' needs were investigated using the critical care family needs inventory and the patients' clinical profiles were investigated using the hospital anxiety and depression scale, confusion assessment method and Karnofsky performance status. The frequencies of family members' needs were described and the patients' clinical and psychiatric characteristics were correlated with the needs using the chi-squared test. RESULTS: Chronic patients predominated and the needs for reassurance and information were indicated as the most important by all members of their families. No associations were found between the patients' characteristics and the needs of members of their families during the hospitalization. CONCLUSIONS: The needs indicated by members of the families of general hospital inpatients were similar to those of members of the families of patients in intensive care units: they considered it very important to be reassured and kept informed throughout the hospitalization.

PMID: 18553038 [PubMed - indexed for MEDLINE]

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Jun 152009
 
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Impact of guidelines on outcome: the evidence.

Semin Respir Crit Care Med. 2009 Apr;30(2):172-8

Authors: Martínez R, Reyes S, Lorenzo MJ, Menéndez R

Pneumonia continues to be the main cause of death due to infection in the world, and it produces a high consumption of healthcare resources. The guidelines established by the scientific societies improve the care of patients with pneumonia. One way of evaluating the effect of the guidelines is to analyze their impact on the prognosis of the infection. To evaluate this effect, cohort studies have been performed using before-after, observational, cost-effectiveness, and, to a lesser degree, randomized designs. The most recent studies show that the implementation of the guidelines is accompanied by an increase in the process of care percentage and a lower inpatient hospital mortality rate- including the first 48 hours and after 30 days. These findings are consistent across various studies, and they have been confirmed in patients admitted to the intensive care unit. Clinical stability is also reached earlier in patients hospitalized for community-acquired pneumonia (CAP) when the antibiotic treatment is begun early and complies with the recommendations. Finally, the choice of antibiotics that adhere to the guidelines is cost-effective in CAP requiring hospitalization, which is responsible for 80% of the total cost of this disease.

PMID: 19296417 [PubMed - indexed for MEDLINE]

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Jun 152009
 
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Application of a biochemical and clinical model to predict individual survival in patients with end-stage liver disease.

World J Gastroenterol. 2009 Jun 14;15(22):2768-77

Authors: Gomez EV, Bertot LC, Oramas BG, Soler EA, Navarro RL, Elias JD, Jiménez OV, Abreu Vazquez MR

AIM: To investigate the capability of a biochemical and clinical model, BioCliM, in predicting the survival of cirrhotic patients. METHODS: We prospectively evaluated the survival of 172 cirrhotic patients. The model was constructed using clinical (ascites, encephalopathy and variceal bleeding) and biochemical (serum creatinine and serum total bilirubin) variables that were selected from a Cox proportional hazards model. It was applied to estimate 12-, 52- and 104-wk survival. The model's calibration using the Hosmer-Lemeshow statistic was computed at 104 wk in a validation dataset. Finally, the model's validity was tested among an independent set of 85 patients who were stratified into 2 risk groups (low risk </= 8 and high risk > 8). RESULTS: In the validation cohort, all measures of fit, discrimination and calibration were improved when the biochemical and clinical model was used. The proposed model had better predictive values (c-statistic: 0.90, 0.91, 0.91) than the Model for End-stage Liver Disease (MELD) and Child-Pugh (CP) scores for 12-, 52- and 104-wk mortality, respectively. In addition, the Hosmer-Lemeshow (H-L) statistic revealed that the biochemical and clinical model (H-L, 4.69) is better calibrated than MELD (H-L, 17.06) and CP (H-L, 14.23). There were no significant differences between the observed and expected survival curves in the stratified risk groups (low risk, P = 0.61; high risk, P = 0.77). CONCLUSION: Our data suggest that the proposed model is able to accurately predict survival in cirrhotic patients.

PMID: 19522028 [PubMed - in process]

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Jun 152009
 
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Impact of a Pre-Clinical Clinical Skills Curriculum on Student Performance in Third-Year Clerkships.

J Gen Intern Med. 2009 Jun 12;

Authors: Jackson MB, Keen M, Wenrich MD, Schaad DC, Robins L, Goldstein EA

BACKGROUND: Research on the outcomes of pre-clinical curricula for clinical skills development is needed to assess their influence on medical student performance in clerkships. OBJECTIVE: To better understand the impact of a clinical-skills curriculum in the pre-clinical setting on student performance. DESIGN: We conducted a non-randomized, retrospective, pre-post review of student performance evaluations from 3rd-year clerkships, before and after implementation of a clinical-skills curriculum, the Colleges (2001-2007). MAIN RESULTS: Comparisons of clerkship performance data revealed statistically significant differences favoring the post-Colleges group in the Internal Medicine clerkship for 9 of 12 clinical-skills domains, including Technical Communication Skills (p < 0.023, effect size 0.16), Procedural Skills (p < 0.031, effect size 0.17), Communication Skills (p < 0.003, effect size 0.21), Patient Relationships (p < 0.003, effect size 0.21), Professional Relationships (p < 0.021, effect size 0.17), Educational Attitudes (p < 0.001, effect size 0.24), Initiative and Interest (p < 0.032, effect size 0.15), Attendance and Participation (p < 0.007, effect size 0.19), and Dependability (p < 0.008, effect size 0.19). Statistically significant differences were identified favoring the post-Colleges group in technical communication skills for three of six basic clerkships (Internal Medicine, Surgery, and Pediatrics). CONCLUSIONS: Implementation of a pre-clinical fundamental skills curriculum appears to be associated with improved clerkship performance in the 3rd year of medical school, particularly in the Internal Medicine clerkship. Similar curricula, focused on teaching clinical skills in small groups at the bedside with personalized mentoring from faculty members, may improve student performance. Continued efforts are needed to understand how to best prepare students for clinical clerkships and how to evaluate outcomes of similar pre-clinical skills programs.

PMID: 19521738 [PubMed - as supplied by publisher]

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