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Microbiological and genotypic analysis of methicillin-resistant Staphylococcus aureus bacteremia.

Antimicrob Agents Chemother. 2008 Sep;52(9):3441-3

Authors: McCalla C, Smyth DS, Robinson DA, Steenbergen J, Luperchio SA, Moise PA, Fowler VG, Sakoulas G

In a recent landmark trial of bacteremia caused by methicillin-resistant Staphylococcus aureus (MRSA) isolates, vancomycin MICs were >or=1 microg/ml for only 16% of the isolates, and accessory gene regulator (agr) function as measured by delta-hemolysin activity was absent or reduced in only 28.1% of the isolates. This clinical study did not capture a population of MRSA isolates predictive of vancomycin treatment failure.

PMID: 18606839 [PubMed - indexed for MEDLINE]

Link to Abstract at PubMed